Impact of JAK2V617F Mutation Burden on Disease Phenotype in Chinese Patients with JAK2V617F-positive Polycythemia Vera (PV) and Essential thrombocythemia (ET)
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چکیده
منابع مشابه
Impact of JAK2V617F Mutation Burden on Disease Phenotype in Chinese Patients with JAK2V617F-positive Polycythemia Vera (PV) and Essential thrombocythemia (ET)
Most patients with polycythemia vera (PV) and half of essential thrombocythemia (ET) possess an activating JAK2V617F mutation. The objective of this study was to better define the effect of JAK2V617F mutant allele burden on clinical phenotypes in Chinese patients, especially thrombosis. By real-time polymerase chain reaction (RT-PCR), the JAK2V617F mutation burden was detected in 170 JAK2V617F-...
متن کاملInfluence of JAK2V617F allele burden on phenotype in essential thrombocythemia.
BACKGROUND Fifty to sixty percent of patients with essential thrombocythemia harbor the JAK2(V617F) mutation. The impact of this mutation on clinical phenotype is still debated. The aim of this study was to evaluate possible correlations between JAK2(V617F) mutant allele burden and both clinical presentation and hematologic abnormalities in essential thrombocythemia patients. DESIGN AND METHO...
متن کاملJAK2V617F mutation and hydroxyurea treatment as determinants of immature platelet parameters in essential thrombocythemia and polycythemia vera patients.
Immature platelets (IPFs), which are hemostatically more active than mature platelets, have been found elevated in essential thrombocythemia and polycythemia vera, 2 myeloproliferative neoplasms (MPN) characterized by an increased risk of thrombosis. It is not known whether the IPF levels are influenced by pathogenetic factors, including JAK2V617F mutational status, or by treatment regimen. To ...
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| 144 | haematologica | 2009; 94(1) Planker, Rudolf Pihusch, Rudolf Weide, Wolfgang Kern, and Torsten Haferlach MLL Munich Leukemia Laboratory, Munich; Clinic for Stem Cell Transplantation, University Hospital of Hamburg, Hamburg-Eppendorf; University Hospital of Essen, Department of Bone Marrow Transplantation, Essen; Munich Oncology Practice, MVZ Elisenhof, Munich; Hematology & Oncology Pract...
متن کاملInterferon apha 2b for treating patients with JAK2V617F positive polycythemia vera and essential thrombocytosis.
OBJECTIVE To investigate interferon (IFN) alpha 2 b for treating patients with JAK2V617F positive polycythemia vera (PV) and essential thrombocytosis (ET). METHODS Interferon alpha 2 b was used to treat patients with JAK2V617F positive PV and ET. In control group, hydroxyurea was used. Endpoint of study was to compare rates of hematological and molecular remission. RESULTS Patients in the i...
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ژورنال
عنوان ژورنال: International Journal of Medical Sciences
سال: 2016
ISSN: 1449-1907
DOI: 10.7150/ijms.10539